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Applications of Light Scattering to HIV Integrase Structural Biology and Drug Discovery


Presented Live: February 24, 2018

Speakers: Kushol Gupta, Ph.D.

We apply multiple biophysical techniques to the study of HIV integrase and the antiviral effects of small molecules that target this protein, including X-ray crystallography, small angle X-ray scattering, and analytical ultracentrifugation. Light scattering measurements, including SEC-MALS and DLS, are key enablers of this ongoing research. In the webinar I will describe how all of these techniques come together and complement each other to provide deeper understanding of the structure and function of HIV integrase, more effective screening of anti-HIV integrase compounds, and a complete picture of the therapeutic mechanism of arising drug candidates.


  Webinar Q & A




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Wyatt Technology is the recognized leader in light scattering instrumentation and software for determining the absolute molar mass, size, charge and interactions of macromolecules and nanoparticles in solution.

Wyatt's line of multi-angle static light scattering products couple to size exclusion chromatography (SEC-MALS), field-flow fractionation (FFF-MALS), and stop-flow composition-gradient systems (CG-MALS). Our dynamic light scattering (DLS) products operate in traditional cuvette as well as on-line and automated, high-throughput modes. We also offer unique instruments for electrophoretic light scattering (MP-PALS), differential refractometry, and differential viscosity.

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