Wyatt Technology

Automated Characterization of Proteins, Polymers and Nanoparticles with DLS


Presented Live: September 15, 2011

Topics Covered

  • An introduction/review of Dynamic Light Scattering (DLS), and discussion of information which DLS can and cannot provide
  • Throughput and sample requirements for the current state of the art instrumentation
  • Example applications including formulation/stability, temperature dependence (e.g., protein "melting"), viscosity measurements using DLS, concentration dependence to determine solubility/critical micelle concentration/KD, and also the measurement of molecular association coefficients using DLS




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Wyatt Technology is the recognized leader in light scattering instrumentation and software for determining the absolute molar mass, size, charge and interactions of macromolecules and nanoparticles in solution.

Wyatt's line of multi-angle static light scattering products couple to size exclusion chromatography (SEC-MALS), field-flow fractionation (FFF-MALS), and stop-flow composition-gradient systems (CG-MALS). Our dynamic light scattering (DLS) products operate in traditional cuvette as well as on-line and automated, high-throughput modes. We also offer unique instruments for electrophoretic light scattering (MP-PALS), differential refractometry, and differential viscosity.

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