Vaccines, Well Characterized? Light Scattering Solutions for Biophysical Characterization in Vaccine R&D

Michelle Chen

Presented by: Michelle Chen, Ph.D., Director of Analytical Services, Wyatt Technology
Presented Live: December 3, 2014

In this webinar we present a comprehensive suite of analytical techniques based on light scattering. These essential R&D tools are vital to the biophysical characterization of macromolecules such as proteins and polymers, as well as VLPs, viruses and other nanoparticles that constitute modern vaccines.

Case studies will show how multi-angle light scattering (MALS) and dynamic light scattering (DLS) instrumentation - whether in standalone mode or in combination with a separation system, such as SEC or FFF – solve key analytical challenges in vaccine development, formulation and quality control.

Topics covered:

  • Determination of molar mass, size and composition for biopolymers and protein-polysaccharide conjugate vaccines, by SEC-MALS
  • High-resolution characterization of size, conformation and composition of virus, VLP, liposome, and emulsion nanoparticles, by FFF-MALS
  • High-throughput vaccine formulation and stability studies, by plate-based DLS
  • Label-free, immobilization-free analysis of antigen-antibody and more complex biomolecular interactions, by CG-MALS

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