Wyatt Technology

Vaccines, Well Characterized? Light Scattering Solutions for Biophysical Characterization in Vaccine R&D


Presented Live: December 3, 2014

In this webinar we present a comprehensive suite of analytical techniques based on light scattering. These essential R&D tools are vital to the biophysical characterization of macromolecules such as proteins and polymers, as well as VLPs, viruses and other nanoparticles that constitute modern vaccines.

Case studies will show how multi-angle light scattering (MALS) and dynamic light scattering (DLS) instrumentation - whether in standalone mode or in combination with a separation system, such as SEC or FFF – solve key analytical challenges in vaccine development, formulation and quality control.

Topics covered:

  • Determination of molar mass, size and composition for biopolymers and protein-polysaccharide conjugate vaccines, by SEC-MALS
  • High-resolution characterization of size, conformation and composition of virus, VLP, liposome, and emulsion nanoparticles, by FFF-MALS
  • High-throughput vaccine formulation and stability studies, by plate-based DLS
  • Label-free, immobilization-free analysis of antigen-antibody and more complex biomolecular interactions, by CG-MALS


  Webinar Q & A




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Wyatt Technology is the recognized leader in light scattering instrumentation and software for determining the absolute molar mass, size, charge and interactions of macromolecules and nanoparticles in solution.

Wyatt's line of multi-angle static light scattering products couple to size exclusion chromatography (SEC-MALS), field-flow fractionation (FFF-MALS), and stop-flow composition-gradient systems (CG-MALS). Our dynamic light scattering (DLS) products operate in traditional cuvette as well as on-line and automated, high-throughput modes. We also offer unique instruments for electrophoretic light scattering (MP-PALS), differential refractometry, and differential viscosity.

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