Characterization and formulation of therapeutic macromolecules using light scattering

Presented by: Ozan Kumru, Ph.D., University of Kansas Vaccine Analytics and Formulation Center, and Dan Some, Ph.D., Wyatt Technology
Presented Live: March 24, 2021

Given the complexity of biological macromolecules used for therapeutic purposes, detailed characterization is both essential and challenging. Some of the most important tools for analyzing the properties and behavior of biologics are based on multi-angle light scattering and dynamic light scattering, which directly determine molar mass, size, stability and interactions. This webinar will provide a brief introduction to these techniques, then several case studies will be presented that utilized dynamic light scattering (DLS), multi-angle light scattering with size-exclusion chromatography (SEC-MALS), and composition-gradient multi-angle light scattering (CG-MALS) as analytical tools for the characterization and formulation of macromolecules ranging from virus-like particle-based vaccines to monoclonal antibodies.

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