For Effective Protein Quality Control and Aggregate Detection, Couple SEC to Multi-Angle Light Scattering (SEC-MALS)

Felix Gloge

Presented by: Felix Gloge, Ph.D., Application Scientist, Wyatt Technology Europe GmbH

Protein science as well as the exploration of other biomolecules has made an enormous development over recent years. Especially antibodies and similar therapeutic proteins are utilized for diagnostics and therapy on an unprecedented scale. But antibodies and other proteins are prone to forming oligomers and aggregates, which can be the bottleneck in preparation.

In this webinar we present how Multi-Angle Light Scattering coupled to size exclusion chromatography (SEC-MALS) can be used to check protein preparations for aggregates and sample stability. Application examples will show how this technique can help to improve protein cleaning and optimize protein formulation.