Wyatt Technology

For Effective Protein Quality Control and Aggregate Detection, Couple SEC to Multi-Angle Light Scattering (SEC-MALS)


Speaker: Dr. Felix Gloge, Application Scientist, Wyatt Technology Europe GmbH

Protein science as well as the exploration of other biomolecules has made an enormous development over recent years. Especially antibodies and similar therapeutic proteins are utilized for diagnostics and therapy on an unprecedented scale. But antibodies and other proteins are prone to forming oligomers and aggregates, which can be the bottleneck in preparation.

In this webinar we present how Multi-Angle Light Scattering coupled to size exclusion chromatography (SEC MALS) can be used to check protein preparations for aggregates and sample stability. Application examples will show how this technique can help to improve protein cleaning and optimize protein formulation.




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Wyatt Technology is the recognized leader in light scattering instrumentation and software for determining the absolute molar mass, size, charge and interactions of macromolecules and nanoparticles in solution.

Wyatt's line of multi-angle static light scattering products couple to size exclusion chromatography (SEC-MALS), field-flow fractionation (FFF-MALS), and stop-flow composition-gradient systems (CG-MALS). Our dynamic light scattering (DLS) products operate in traditional cuvette as well as on-line and automated, high-throughput modes. We also offer unique instruments for electrophoretic light scattering (MP-PALS), differential refractometry, and differential viscosity.

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