From Aggregation to Impurity Profiling: Analytical Best Practices for GLP-1RAs
Presented by: Bill Warren and Neil J. Lander (Waters Corporation)
Presented Live: September 16, 2025
As GLP-1 receptor agonists (GLP-1RAs) continue to transform the treatment landscape for metabolic disorders, ensuring the integrity and quality of these complex molecules is more critical than ever. This webinar explores advanced analytical strategies for characterizing critical quality attributes (CQAs), with a focus on Size-Exclusion Chromatography with Multi-Angle Light Scattering (SEC-MALS) and Reversed-Phase Chromatography with Mass Spectrometry (RPC-MS).
Attendees will gain insights into SEC column selection for impurity profiling, the use of native vs. denaturing SEC for aggregation analysis, and the comparative strengths of MALS and MS detection. The session also features a side-by-side analysis of liraglutide and semaglutide, demonstrating how integrated data workflows using Empower CDS with MALS streamline complex analyses while supporting compliance requirements and product quality.
With built-in tools for method standardization, secure data handling, and audit-trail integrity, Empower CDS helps laboratories meet regulatory expectations while improving efficiency. Whether you're developing or monitoring GLP-1RAs, this session offers practical guidance and best practices using the Waters end-to-end LC, column, detector, and software solutions.