Predicting stability of antibody therapeutics by unfolded-state studies with high-throughput dynamic light scattering (HT-DLS)
Presented by: Robin Curtis, Ph.D., University of Manchester
Presented Live: August 18, 2020
The presentation highlights recent applications of high-throughput dynamic light scattering (HT-DLS) for quantifying the colloidal stability of antibody therapeutics, and the relationship to storage stability. Aggregation driven by association of partially-folded or unfolded states is the main degradation route of such molecules, but its characterization is difficult due to the transient nature and low abundance of these states. Overcoming this difficulty requires orthogonal approaches for measuring self-association over a range of native and stressed formulation conditions.
