Presented by: Anatolii Purchel, Ph.D., Wyatt Technology
Presented Live: April 20, 2021
Lentiviral and gammaretroviral vectors are the most popular retroviral vectors used in gene and cell therapies with more than 300 clinical trials currently underway in Phase II and Phase III. Quantifying quality attributes of these retroviral vectors is of increasing importance as they enter into the late development stages. In this webinar we demonstrate the use of two analytical techniques, batch dynamic light scattering (DLS) for rapid, low-resolution measurements and multi-angle light scattering in combination with field-flow fractionation (FFF-MALS) for extended characterization of viral vectors. We will discuss methods for evaluation of the size distribution and physical titer, impurity profiling, in-depth assessment of aggregation, and lot-to-lot variability.