Wyatt Technology

Quantifying Affinity and Stoichiometry of Biomolecular Interactions by Composition-Gradient Multi-Angle Light Scattering (CG-MALS)


Presented Live: April 23, 2013

Composition-Gradient, Multi-Angle Light Scattering (CG-MALS) is a powerful, label-free technique for quantifying the affinity and stoichiometry of macromolecular interactions. CG-MALS measures interactions entirely in solution without tagging or immobilization, which can confound measurements by other techniques. In this webinar, we will demonstrate how CG-MALS has been successfully applied to the study of self-association, hetero-association with simple stoichiometry, and complex combinations of self- and hetero-association.


  Webinar Q & A




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Wyatt Technology is the recognized leader in light scattering instrumentation and software for determining the absolute molar mass, size, charge and interactions of macromolecules and nanoparticles in solution.

Wyatt's line of multi-angle static light scattering products couple to size exclusion chromatography (SEC-MALS), field-flow fractionation (FFF-MALS), and stop-flow composition-gradient systems (CG-MALS). Our dynamic light scattering (DLS) products operate in traditional cuvette as well as on-line and automated, high-throughput modes. We also offer unique instruments for electrophoretic light scattering (MP-PALS), differential refractometry, and differential viscosity.

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