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Separation and Characterization of Complex (Bio)macromolecular Architectures

 

Presented Live: April 24, 2018

Speakers: Albena Lederer, Ph.D.

Soft materials such as highly-branched, responsive or dynamic polymers have great potential for advanced applications. The basis for this potential is the versatility, tunability and high functionality of the polymer systems and of their well-defined nanoscale structures. Understanding these materials and how to adjust their scaling parameters on a molecular level is crucial for controlled design to meet application requirements.
In this webinar, I compare techniques for characterizing the properties and interactions of highly-functionalized polymers, highly-branched polymers, biohybrids and similar complex systems. These techniques include field-flow fractionation coupled to multiple types of detectors, and complementary methods such as AFM, cryo-TEM and MD simulations. I also discuss the relation between conformation and interactions, which is highly relevant for biological applications.

 

   

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Wyatt Technology is the recognized leader in light scattering instrumentation and software for determining the absolute molar mass, size, charge and interactions of macromolecules and nanoparticles in solution.

Wyatt's line of multi-angle static light scattering products couple to size exclusion chromatography (SEC-MALS), field-flow fractionation (FFF-MALS), and stop-flow composition-gradient systems (CG-MALS). Our dynamic light scattering (DLS) products operate in traditional cuvette as well as on-line and automated, high-throughput modes. We also offer unique instruments for electrophoretic light scattering (MP-PALS), differential refractometry, and differential viscosity.



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