AN1605: Identification of Insulin Oligomeric States

Insulin Oligomeric

This application note shows how the combination of column chromatography (SEC/GPC) with multi-angle light scattering (MALS) can be applied as a powerful tool to identify monomers, dimers, hexamers and higher aggregates of insulin.

Using this approach, each preparation can be comprehensively characterized to determine optimal formulation, storage and administration conditions.