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AN5002: High-Throughput Optimization of Drug Nanosuspensions

This application note describes a plate-based method for early process development of a compound in nanoparticle format that is rapid and requires very little material, combining acoustic resonance milling and automated DLS. These qualities make it appropriate for implementation in the discovery phase where a nimble strategy is imperative.


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Wyatt Technology is the recognized leader in light scattering instrumentation and software for determining the absolute molar mass, size, charge and interactions of macromolecules and nanoparticles in solution.

Wyatt's line of multi-angle static light scattering products couple to size exclusion chromatography (SEC-MALS), field-flow fractionation (FFF-MALS), and stop-flow composition-gradient systems (CG-MALS). Our dynamic light scattering (DLS) products operate in traditional cuvette as well as on-line and automated, high-throughput modes. We also offer unique instruments for electrophoretic light scattering (MP-PALS), differential refractometry, and differential viscosity.

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