pH Dependent Monomer-Dimer Equilibrium Constants for Glycinamide ribonucleotide transformylase (GART)

Glycinamide ribonucleotide transformylase (GART) catalyzes formyl group transfer in the de novo purine biosynthetic pathway in cells. Because of the dependence of cancer cell growth on purine, the chemo-therapeutic inhibition of GART and other transformylase enzymes is a potential method for combating cancer.