Characterizing ADCs with the Light Scattering Toolbox

Chris Broomell

Presented by: Chris Broomell, Ph.D., Applications Scientist, Wyatt Technology
Presented Live: June 4, 2014

Topics Covered

  • Which biophysical properties of Antibody-Drug Conjugates (ADCs) are measured by different light scattering techniques and the range of measurements
  • How ADC formulations are rapidly screened for stability by high-throughput DLS
  • How drug-antibody ratio (DAR) is analyzed by triple-detection SEC-MALS
  • How soluble and insoluble sub-micron aggregates are characterized by FFF-MALS