Wyatt Technology

Characterizing ADCs with the Light Scattering Toolbox


Presented Live: June 4, 2014

Speaker: Chris Broomell, Applications Scientist

Topics Covered

  • Which biophysical properties of Antibody-Drug Conjugates (ADCs) are measured by different light scattering techniques, and the range of measurements
  • How ADC formulations are rapidly screened for stability by high-throughput DLS
  • How drug-antibody ratio (DAR) is analyzed by triple-detection SEC-MALS
  • How soluble and insoluble sub-micron aggregates are characterized by FFF-MALS


  Webinar Q & A




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Wyatt Technology is the recognized leader in light scattering instrumentation and software for determining the absolute molar mass, size, charge and interactions of macromolecules and nanoparticles in solution.

Wyatt's line of multi-angle static light scattering products couple to size exclusion chromatography (SEC-MALS), field-flow fractionation (FFF-MALS), and stop-flow composition-gradient systems (CG-MALS). Our dynamic light scattering (DLS) products operate in traditional cuvette as well as on-line and automated, high-throughput modes. We also offer unique instruments for electrophoretic light scattering (MP-PALS), differential refractometry, and differential viscosity.

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