High-Throughput, Automated Dynamic Light Scattering Using the DynaPro Plate Reader

Sigrid Kuebler

Presented by: Sigrid Kuebler, Ph.D., Director of Customer Service & Support, Wyatt Technology
Presented Live: March 24, 2009

Dynamic light scattering (DLS) is an established technique for determining the size of submicron particles, such as proteins and other biomolecules, liposomes, nanoparticles and compound aggregates. With the DynaPro Plate Reader, a multitude of sample conditions, such as buffer compositions, concentrations, time and temperature stability, can be screened automatically and directly in disposable microwell plates. Applications are presented on determining particle size and size distribution, unfolding of biomolecules, screening proteins for crystallizability, thermal stability, and aggregation and solubility behavior.

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