Wyatt Technology

High-Throughput, Automated Dynamic Light Scattering Using the DynaPro Plate Reader


Presented Live: March 24, 2009

Dynamic light scattering (DLS) is an established technique for determining the size of submicron particles, such as proteins and other biomolecules, liposomes, nanoparticles and compound aggregates. With the DynaPro Plate Reader, a multitude of sample conditions, such as buffer compositions, concentrations, time and temperature stability, can be screened automatically and directly in disposable microwell plates. Applications are presented on determining particle size and size distribution, unfolding of biomolecules, screening proteins for crystallizability, thermal stability, and aggregation and solubility behavior.




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Wyatt Technology is the recognized leader in light scattering instrumentation and software for determining the absolute molar mass, size, charge and interactions of macromolecules and nanoparticles in solution.

Wyatt's line of multi-angle static light scattering products couple to size exclusion chromatography (SEC-MALS), field-flow fractionation (FFF-MALS), and stop-flow composition-gradient systems (CG-MALS). Our dynamic light scattering (DLS) products operate in traditional cuvette as well as on-line and automated, high-throughput modes. We also offer unique instruments for electrophoretic light scattering (MP-PALS), differential refractometry, and differential viscosity.

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