Multi-Detector Asymmetric-Flow Field-Flow Fractionation for Nanoparticle Analysis in Complex Matrices

Presented by: Stacey Louie, Ph.D., University of Houston and Nemal Gobalasingham, Ph.D., Waters | Wyatt Technology
Presented Live: July 25, 2023

Nanomaterials are surging in interest for a variety of applications: medicine, agriculture and more. However, the environmental effects of nanoscale materials such as nanoplastics are of increasing concern. Beyond potential toxicities of the nanomaterials themselves, nanoparticles can serve as carriers of other chemicals, for example active pharmaceutical ingredients or environmental pollutants.

The challenges associated with detecting and characterizing nanomaterials in the environment include exposure to a complex matrix that can interfere with their detection and may induce particle degradation, chemical release or other transformations.

Multi-detector asymmetric-flow field–flow fractionation (MD-AF4) is a versatile technique for separating nanoparticles from complex matrices and characterizing their size and compositional analysis.

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