Optimizing Development and Release Efficiency of Protein, AAV and LNP Therapies Using Multi-Attribute Quantification (MAQ) Light Scattering

Michelle Chen

Presented by: Michelle Chen, Ph.D., Waters | Wyatt Technology
Presented Live: November 1, 2023

Light scattering (LS) techniques, both dynamic LS (DLS) and multi-angle static LS (MALS), have been used as important biophysical characterization and quantification tools for biopharmaceuticals for the past decades. For proteins, DLS, especially in the plate reader format, is used to screen for aggregation presence and propensity and formulation conditions, whereas MALS combined with size exclusion chromatography (SEC) is employed throughout the development cycle of the protein therapeutics.

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