Quantify Viral Vector Attributes with Light Scattering

John Champagne

Presented by: John Champagne, Ph.D., Wyatt Technology
Presented Live: January 19, 2021

Adeno-associated virus (AAV) is an attractive delivery vehicle in gene therapy attributed to its mild immune response and ability to deliver its genome into a wide range of host cells. In this presentation, we will discuss a method to measure the following three important AAV quality attributes (QAs): 1) total number of viral capsid particles; 2) relative capsid content (e.g., ratio of empty and full capsids); and 3) percentage of monomer or aggregates.

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