Wyatt Technology

Screening & Characterizing Biomolecular Interactions via Light Scattering for Biotherapeutic R&D: Part I – High-Throughput Screening by DLS


Presented Live: June 26, 2013

Multiple stages in the biotherapeutics R&D pipeline require analysis of protein-protein and other biomolecular interactions, whether in the form of high-throughput screening or in-depth characterization. Static and dynamic light scattering are versatile, label-free, immobilization-free techniques that provide unique insights for a broad range of interactions. In Part I of this webinar series we present a high-throughput, automated dynamic light scattering tool for accomplishing these measurement tasks, and review how it is employed at each stage.

Topics Covered

  • High-throughput screening of interactions using a dynamic light scattering plate reader (HTS-DLS)
  • HTS-DLS applications in the R&D pipeline, especially developability/pre-formulation and formulation


  Webinar Q & A




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Wyatt Technology is the recognized leader in light scattering instrumentation and software for determining the absolute molar mass, size, charge and interactions of macromolecules and nanoparticles in solution.

Wyatt's line of multi-angle static light scattering products couple to size exclusion chromatography (SEC-MALS), field-flow fractionation (FFF-MALS), and stop-flow composition-gradient systems (CG-MALS). Our dynamic light scattering (DLS) products operate in traditional cuvette as well as on-line and automated, high-throughput modes. We also offer unique instruments for electrophoretic light scattering (MP-PALS), differential refractometry, and differential viscosity.

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