AN1616: SEC-MALS method for characterizing mRNA

Characterizing mRNA

A SEC-MALS method incorporating DAWN® and Optilab® detectors is developed to quantify a number of biophysical attributes of mRNA. These attributes include molecular weight, percentage of aggregates, Rg, Rh, and Rg/Rh. This method can be readily adopted to further study how these attributes are being affected by mRNA preparation, formulation and storage conditions.