Wyatt and Waters Software Integration

We are excited to offer our customers the benefit of wider choices as a result of the deep investments we are making in an integrated Waters and Wyatt portfolio. This includes an integrated software for Waters LC and Wyatt instruments. Today we offer several options for connecting to our instruments:

The Present:
Digital and Analog
Waters-Wyatt Connectivity

Wyatt Technology’s ASTRA software and family of DAWN MALS detectors are digitally integrated with the Waters Arc Premier. This LC is controlled by the ASTRA software through HPLC CONNECT. Customers with an Arc Premier and Wyatt MALS instruments can purchase HPLC CONNECT 4 today and take advantage of integration with the ASTRA software.

HPLC CONNECT for Waters allows scientists to run SEC-MALS from a single, familiar environment using the ASTRA software’s full digital synchronization. This minimizes user errors by allowing the ASTRA software to control the Waters HPLC stack, import digital UV signals, control fraction collectors, and monitor status of key Waters components from the ASTRA software.

The Future:
More Digital Waters-Wyatt Integration

Other LC systems from Waters are still supported through analog connections. This configuration supports transfer of multiple Waters UV or RI signals and the contact closure signal from an autosampler (to synchronize sample injection and data collection) into the ASTRA software. See TN3601: Waters HPLC Connection Guide for Wyatt Instrumentation and TN3610: ACQUITY UPLC Connection Guide for Wyatt Instrumentation.

We expect this new version of HPLC CONNECT to support ACQUITY Premier systems in early 2024. Support for Waters LC modules in VISION software with Eclipse FFF systems is also expected by early 2024.

Special offer for 2023

For customers interested in integrating Waters and Wyatt instruments in 2023, when you purchase an ACQUITY Premier System with a Wyatt MALS instrument and ASTRA software, you will receive a copy of HPLC CONNECT for seamless digital integration at the time of release. For any system that has previously been quoted with an alternative LCs, a Waters LC can be quoted in its place and will be supported now and in the future.


Together, Waters and Wyatt will continue to invest in integrated solutions to help scientists accelerate the collection of scientific information necessary for innovative research.

Contact us below to learn more about integrated Waters and Wyatt instruments.