From Mobility to Stability: Light Scattering Solutions for Formulating Stable Biotherapeutics

Chris Broomell

Presented by: Chris Broomell, Ph.D., Applications Scientist, Wyatt Technology
Presented Live: May 14, 2013

Topics Covered

  • High-throughput screening (HTS) DLS, performed directly in microwell plates, to qualify buffer conditions for aggregation, colloidal stability, thermal stability and viscosity
  • SEC-MALS and FFF-MALS for quantifying aggregates in a stability course study
  • MP-PALS for determining net charge
  • CG-MALS for characterizing self-association/self-interaction and protein-excipient interactions at moderate to high protein concentrations, as well as protein-target binding