Wyatt Technology

From Mobility to Stability: Light Scattering Solutions for Formulating Stable Biotherapeutics


Presented Live: May 14, 2013

Speaker: Dr. Chris Broomell, Applications Scientist

Topics Covered

  • High-throughput screening (HTS) DLS, performed directly in microwell plates, to qualify buffer conditions for aggregation, colloidal stability, thermal stability and viscosity
  • SEC-MALS and FFF-MALS for quantifying aggregates in a stability course study
  • MP-PALS for determining net charge
  • CG-MALS for characterizing self-association/self-interaction and protein-excipient interactions at moderate to high protein concentrations, as well as protein-target binding




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Wyatt Technology is the recognized leader in light scattering instrumentation and software for determining the absolute molar mass, size, charge and interactions of macromolecules and nanoparticles in solution.

Wyatt's line of multi-angle static light scattering products couple to size exclusion chromatography (SEC-MALS), field-flow fractionation (FFF-MALS), and stop-flow composition-gradient systems (CG-MALS). Our dynamic light scattering (DLS) products operate in traditional cuvette as well as on-line and automated, high-throughput modes. We also offer unique instruments for electrophoretic light scattering (MP-PALS), differential refractometry, and differential viscosity.

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