Wyatt Technology

MP-PALS improves over conventional Phase Analysis Light Scattering to determine electrophoretic mobility and charge with maximum sensitivity and minimal damage to fragile biomolecules.


Electrophoretic Light Scattering (ELS) is used widely for characterizing electrophoretic mobility, zeta potential or charge of nanoparticles. Wyatt Technology's breakthrough Massively Parallel Phase Analysis Light Scattering (MP-PALS) extends robust ELS measurements to proteins and other biomolecules in native buffer solutions.

MP-PALS does everything conventional zeta potential instruments can do and much more:

  • Optimize stability of colloidal suspensions or biomolecular formulations
  • Evaluate degradation due to accelerated stress of proteins
  • Understand the different factors contributing to intermolecular forces
  • Analyze compositional variants of biopolymers
Mobility Graph

Protein electrophoretic mobility as a function of formulation pH.

MP-PALS Detectors
MP-PALS utilizes low voltage and multiple low-noise, high-dynamic range detectors in parallel to achieve
the highest sensitivity without damaging fragile samples.


Instrumentation for MP-PALS

  • MP-PALS Detector

    mobius-atlas, MP-PALS, zeta potential, zeta potential instrument, zetasizer, electrophoretic mobility, isoelectric point, dn/dc

    Mobius™ - Massively Parallel Phase Analysis Light Scattering makes the Mobius the most sensitive electrophoretic light scattering detector available. Determines electrophoretic mobility, surface charge and zeta potential of fragile biomolecules as well as more robust nanoparticles, in native buffer. The Mobius is the only mobility detector to provide connectivity to an autosampler for hands off, multi-sample operation.

    The Mobius is also the only mobility detector that measures dynamic light scattering (DLS) simultaneously with electrophoretic mobility, in the same scattering volume, to monitor potential sample degradation.

  • Accessories

    mobius dip cell, MP-PALS, zeta potential, zeta potential instrument, zetasizer, electrophoretic mobility, isoelectric point, dn/dc

    Atlas™ - Pressurizes the Mobius cell to allow mobility measurements of samples, including proteins and vesicles, in high-salt buffers.

    Mobius Dip Cell - An alternative to the high-pressure flow cell, the Mobius Dip Cell facilitates rapid manual measurements while requiring only 65 µL of solution under typical conditions.

    NanoFilter Kit - Makes it easy to filter, recover and refilter precious sample. This is especially useful when your total sample volumes are below 300 µL.

    Microbatch Kit - Used to inject samples into the flow cell of the Mobius, and requires a minimum volume of 300 µL.

  • Software

    DYNAMICS software

    DYNAMICS® - Software for MP-PALS and DLS measurements in the Mobius. Calculates electrophoretic mobility, size and size distributions, and derives zeta potential, Debye-Hückel-Henry and effective net charge.


Ultimate Guide

Thirteen key questions to ask when buying a Multi-Angle Light Scattering (MALS) or Dynamic Light Scattering (DLS) instrument.

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Wyatt Technology is the recognized leader in light scattering instrumentation and software for determining the absolute molar mass, size, charge and interactions of macromolecules and nanoparticles in solution.

Wyatt's line of multi-angle static light scattering products couple to size exclusion chromatography (SEC-MALS), field-flow fractionation (FFF-MALS), and stop-flow composition-gradient systems (CG-MALS). Our dynamic light scattering (DLS) products operate in traditional cuvette as well as on-line and automated, high-throughput modes. We also offer unique instruments for electrophoretic light scattering (MP-PALS), differential refractometry, and differential viscosity.

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