Meet Wyatt Technology’s NEON line of multi-angle light scattering instruments, based on the award-winning DAWN®, Optilab® and ViscoStar® products. The NEON generation provides the same industry‐leading performance specifications our users have come to expect from Wyatt, while breaking new ground for enhanced productivity.

The DAWN MALS instrument and its companion products have been built around an all new Smart Services Platform and redesigned to meet the users’ expectations for on-site serviceability and an intuitive, convenient graphical user interface.

Product Overview

Hear from Wyatt’s leaders and experts about the next generation instruments and their new features.

Smart Services Platform


The new generation of SEC-MALS instruments incorporates an advanced platform, based around a modern user interface that guides the user toward making optimal measurements.

Before running any experiment, you need to know, “Is my system ready?” That includes the chromatography hardware, column, mobile phase, and your Wyatt detectors. The new front panel design shows you at a glance if your whole system is ready so that you can be confident in your light scattering data. If not, it provides guidance on how to bring the system to top performance.

The new large displays incorporate multi-touch interactivity with swipe and zoom capabilities, giving it the feel of a modern tablet or smartphone application. Click on the bars below to find out about additional Smart Services features.


Never waste a run due to incomplete equilibration, excessive mobile-phase noise or sub-optimal detector state. The System Ready Monitor simply does that for you and continuously reports if all systems are go right from the front panel.

If problems do arise, the System Ready Monitor alerts you by changing from green to yellow to red depending on the severity and also provides actionable, real-time guidance on what needs to be done to bring the system back to peak health.


System Ready Monitor indicating that not all is well? For more detailed information on what’s holding you back, review the Real-Time Health indicators. Perhaps the Forward Monitor indicator is triggered by a bubble or the Drift indicator by insufficient column equilibration.

Specific indicators can be customized for more or less stringent requirements. For example, the Noise indicator can be set to have a wider acceptable range for aqueous buffers, which typically exhibit more noise than organic solvents.


Never again worry about a colleague disrupting your experiments. Our dynamic Collection Mode indicator provides a spinning, System Status wheel right from the front panel that can’t be missed.

Want to know who is operating the instrument? Simply click on the collection icon to determine who is logged in and from what computer they are connected.


A unique benefit of Wyatt MALS instruments is their ability to accept an optional embedded dynamic light scattering (DLS) module for inline measurements of hydrodynamic radius. The WyattQELS connects via optical fiber to the DAWN flow cell and collects light scattered from particles in the beam, simultaneously with MALS acquisition.

In order to optimize range and sensitivity for different particle size combinations, the DAWN offers four angular DLS positions—50.5º, 90º, 135º and 150º. These are independent of MALS photodetector positions, and ASTRA will automatically detect the position.


The heart of the DAWN is its flow cell—a highly polished, precision-manufactured glass and metal assembly designed to eliminate stray light for maximum light scattering.

Our exclusive design allows the flow cell to be changed without the need for additional laser or optical alignment. This enables a Wyatt field service engineer to perform a flow cell change in the field, minimizing down time and maximum productivity.


If concerns about the status of your instrument arise, an expert opinion is just a click away. With CheckPlus, our integrated service application, a complete instrument and system history report can be auto-generated at any time and sent to a Wyatt Service Engineer or Application Scientist for further analysis.

This is just another example of how our Smart Services Platform is designed to deliver important customer-facing benefits and simplified use.

Field Serviceability

NEON instruments are designed for full field-serviceability and maximum up-time. A service technician can perform almost all types of maintenance right in your lab.

Self-diagnostics, health monitoring and event logging on all the instruments ensure real-time feedback and recommendations to keep your instruments in top condition. If you ever have any questions about your instruments, the CheckPlus desktop application sends a complete instrument history report to our technical support staff for further analysis.

Should repair be necessary, the modular design of the instruments means that electronics, display or optical modules can be shipped out and installed within a day or two.

MALS: Absolute Characterization

Combining multi-angle light scattering with size exclusion chromatography, SEC-MALS is the preferred analytical technique for determining molar mass, size, conformation and conjugation of peptides, proteins, polymers, vesicles and nanoparticles. SEC-MALS accomplishes all of this without making assumptions about conformation or relying on calibration standards.

A DAWN can also be combined with an Eclipse Field-Flow Fractionation system to characterize complex fluids with particles from 1 – 1,000 nm, and with a Calypso® composition-gradient device to characterize biomolecular interactions.


A complete SEC-MALS system combines MALS, intrinsic viscosity (IV) and differential refractive index (dRI) instruments with leading U/HPLC systems for SEC separation and UV detection.

“SEC-MALS for Absolute Biophysical Characterization”

Read the Whitepaper

“SEC-MALS Method for Characterizing mRNA Biophysical Attributes”

Read the Application Notes


Flow field-flow fractionation (FFF) is a powerful separation technique over a size range of 1 to 10,000 nm. Flow-FFF fractionates and characterizes complex fluids, colloids, nanoparticles, macromolecules and assemblies.

“Exosome Characterization with FFF-MALS-DLS”

Read the Whitepaper

“SEC-MALS Method for Characterizing mRNA Biophysical Attributes”

Read the Brochure


Composition-gradient multi-angle light scattering (CG-MALS) is a label-free, immobilization-free technique for characterizing protein-protein interactions, protein-DNA complexes and other macromolecular interactions.

“Understanding Antibody and Viral Glycoprotein Interactions Using CG-MALS”

Read the Application Note

“SEC-MALS Method for Characterizing mRNA Biophysical Attributes”

Read the Brochure