Wyatt BlogWe welcome blog post submissions from all Wyatt users and staff. To submit a blog, please send your article in a Word document to firstname.lastname@example.org along with any photos or images in separate files.
July 1, 2017
July 1, 2017 - Dynamic light scattering is not just for proteins and nanoparticles. In the field of small-molecule drug discovery, high-throughput DLS with the DynaPro Plate Reader II has at least one key role - preventing the accumulation of misleading hits, or false positives, that are a result of aggregated compounds. Brian Shoichet's UCSF lab has been instrumental in elucidating the mechanism of action and prevention of these promiscuous inhibitors, utilizing the DynaPro PRII for detection and formulation. Read highlights of his publications and a link to a recent online interview.
June 17, 2017
June 17, 2017 - We are pleased to announce to extension of SelectScience's Seal of Quality to the DAWN, following its recognition as Reviewers' Choice Instrument of the Year for 2017. More on the inside story here.
May 31, 2017
May 31, 2017 - When two technology leaders team up to advance the state of the art in polymer and biopharmaceutical characterization, customers can expect to see some real benefits coming down the pipeline. Wyatt and Waters have been collaborating for some time on joint educational efforts around UPLC®, APC and the μDAWN®, but now it is official. In the words of Cliff Wyatt, Executive Vice President of Wyatt Technology, “We’re delighted to be partnering these ‘best in class’ products to improve the accuracy and throughput of our mutual customers.” Click here to read the press release on our co-marketing agreement with Waters.
May 19, 2017
May 19, 2017 - Introducing the next generation miniDAWN: the miniDAWN® TREOS® II. In designing the TREOS II, your productivity was our guiding light. The TREOS II is modular and field-serviceable, adds ease-of-use features to make SEC-MALS even easier, and is upgradeable to a μDAWN. This new instrument is also more sensitive than the previous TREOS and has a larger range of size (hydrodynamic radius) measurement. To download a white paper describing the many improvements introduced in the TREOS II
May 9, 2017
May 9, 2017 - Protein-protein binding studies are only as good as the quality of the reagents used in the experiments. Great resources in terms of instrumentation, sample production and scientist time are typically invested in high-throughput screening of antibodies or fragments to obtain optimal therapeutic candidates, perform epitope binning and rank candidates by affinity and kinetics. However, often little attention is paid to verifying protein solution quality—which can lead researchers down the proverbial rabbit hole, chasing after ephemeral or anomalous results that are caused by degraded proteins. To download a white paper describing a fast, easy and non-perturbing pre-screening method using the DynaPro Plate Reader II.
April 13, 2017
April 13, 2017 – Wyatt Technology, in partnership with the University of Minnesota, presented a polymer characterization seminar in the Twin Cities to over fifty scientists and engineers. Dr. Jeff Ahlgren was the keynote speaker and discussed ways in which size-exclusion chromatography (SEC) or gel permeation chromatography (GPC) coupled with multi-angle light scattering (MALS), refractive index (RI) and differential viscometry can be a powerful technique in determining important polymer characteristics such as: absolute molar mass, size, branching and conformation. Many of our long time and loyal customers attended and got a chance to hear about the latest developments at Wyatt Technology including the new, benchmark-setting ViscoStar III.
April 4, 2017
April 4, 2017 - Most of the boxes have been unpacked. Furniture that didn’t survive the move has been recycled. New logos have been stenciled on the glass. Our company sign has been hoisted into place on the building’s façade.
March 14, 2017
March 14, 2017 - At the recent Pittsburgh Conference (PittCon) held in Chicago, IL March 6-9, 2017, Wyatt Technology was pleasantly surprised to learn that we had won a Scientist’s Choice Award® from SelectScience. The active roster of 300,000+ SelectScience customers were invited to participate in the process by nominating, voting and reviewing companies of their choosing.
March 3, 2017
March 3, 2017 - We are pleased to announce the release of 21CFR(11)-compliant software for the groundbreaking DynaPro® Plate Reader II. The DynaPro PRII is widely used in the biopharmaceutical industry to characterize aggregation as well as thermal, conformational and colloidal stability of biotherapeutics. With the release of the 21CFR11-compliant Security Pack (SP) in DYNAMICS, labs operating under GLP or GMP regulatory requirements may now take advantage of the DynaPro PRII’s automation to measure dozens, hundreds or even thousands of samples per day. DYNAMICS SP also supports the DynaPro NanoStar cuvette-based DLS detector and the Möbius zeta potential/DLS detector.
March 3, 2017
March 3, 2017 - Ligand Binding Assays (LBAs) used for large molecule drug development often utilize proteins conjugated to various tags. To ensure that these conjugated protein reagents perform consistently over time and provide high quality data, each lot of conjugated material should be characterized functionally and biophysically. This application note, contributed by Justin Low et al. at Genentech, discusses the advantages of SEC-MALS for this application and the impact of aggregated reagents on assays used to detect anti-drug antibodies.