Wyatt Blog

We welcome blog post submissions from all Wyatt users and staff. To submit a blog, please send your article in a Word document to marketing@wyatt.com along with any photos or images in separate files.
September 11, 2017
FFF-MALS Illustration

Virtual Method Optimization and Size Analysis for FFF

September 11, 2017 - Flow-field flow fractionation (flow-FFF) offers highly versatile separations for the analysis of complex fluids, covering a size range of macromolecules and particles from 1 nm to 10,000 nm. However, flow-FFF is often perceived as a difficult technique to learn because of the multiple parameters available for adjustment.

Our new SCOUT DPS® software simulates flow-FFF from basic physical principles, enabling the virtual optimization of flow-FFF methods and opening up the power of flow-FFF separations to non-experts. SCOUT DPS also analyzes particle size distributions (hydrodynamic radius) by elution time to increase characterization capabilities. This publication in The Column explains how it works.

August 31, 2017
UHPLC MALS vs. HPLC microMALS

UHP-SEC-MALS Analysis of NIST mAb Reference Material

August 31, 2017 - The µDAWN® multi-angle light scattering (MALS) detector was developed to meet the need for a low-volume, low-dispersion MALS instrument compatible with size-exclusion UHPLC (SE-UHPLC). Congratulations to Drs. Vincent Hsieh and Philip J. Wyatt on the publication of their article, “Measuring proteins with greater speed and resolution while reducing sample size” in Scientific Reports. The paper describes the analysis of NIST standard reference material SRM 8671, a monoclonal antibody developed to benchmark analytical instruments for the biopharmaceutical industry, with the µDAWN.
August 11, 2017
Wyatt Family

Three Wyatt Generations

August 11, 2017 - 3G isn’t just a telecommunications term anymore. It’s also an abbreviation for the three generations of Wyatts working at Wyatt Technology this summer. While there have been 2G—or two generations—of Wyatts working at Wyatt Technology for more than thirty years, this summer we welcomed Spenser Wyatt, Geof’s son, to intern under Ross Bryant, Wyatt Technology’s Vice President for Sales & Marketing, doing Market Research. Besides investigating instrument population density throughout the United States, and researching new sales tools, Spenser has audited Light Scattering University and surveyed students about their experiences at LSU.
August 10, 2017
Christopher Ellison

Featured Customer – Professor Christopher Ellison

August 10, 2017 - It was our pleasure to host Prof. Christopher Ellison at the June LSU (Light Scattering University) course–held, as always, at Wyatt’s headquarters in beautiful Santa Barbara, California. As Piercy Professor of Chemical Engineering and Materials Science at the University of Minnesota, Dr. Ellison’s research pushes the boundaries of molecular architecture: he and his group create and investigate nanostructured polymeric systems for a wide array of advanced applications including photolithography, microelectronic device design, battery design, and general nano-scale manufacturing.
July 1, 2017
Small Molecule Bound to Protein

Drug discovery: Finding, Then Losing, Then Finding Again Colloidal Aggregates of Small-molecule Drugs with DLS

July 1, 2017 - Dynamic light scattering is not just for proteins and nanoparticles. In the field of small-molecule drug discovery, high-throughput DLS with the DynaPro Plate Reader II has at least one key role - preventing the accumulation of misleading hits, or false positives, that are a result of aggregated compounds. Brian Shoichet's UCSF lab has been instrumental in elucidating the mechanism of action and prevention of these promiscuous inhibitors, utilizing the DynaPro PRII for detection and formulation. Read highlights of his publications and a link to a recent online interview.
June 17, 2017
SelectScience Silver Seal of Quality Award

Silver Seal of Quality Awarded for DAWN

June 17, 2017 - We are pleased to announce to extension of SelectScience's Seal of Quality to the DAWN, following its recognition as Reviewers' Choice Instrument of the Year for 2017. More on the inside story here.
May 31, 2017
Acquity with UT-rEX and uDAWN

Joining Forces for Faster Analyses

May 31, 2017 - When two technology leaders team up to advance the state of the art in polymer and biopharmaceutical characterization, customers can expect to see some real benefits coming down the pipeline. Wyatt and Waters have been collaborating for some time on joint educational efforts around UPLC®, APC and the μDAWN®, but now it is official. In the words of Cliff Wyatt, Executive Vice President of Wyatt Technology, “We’re delighted to be partnering these ‘best in class’ products to improve the accuracy and throughput of our mutual customers.” Click here to read the press release on our co-marketing agreement with Waters.
May 19, 2017
TREOS II Video

The Next Generation Compact MALS Detector

May 19, 2017 - Introducing the next generation miniDAWN: the miniDAWN® TREOS® II. In designing the TREOS II, your productivity was our guiding light. The TREOS II is modular and field-serviceable, adds ease-of-use features to make SEC-MALS even easier, and is upgradeable to a μDAWN. This new instrument is also more sensitive than the previous TREOS and has a larger range of size (hydrodynamic radius) measurement. To download a white paper describing the many improvements introduced in the TREOS II
May 9, 2017
Protein Quality Control

Protein Quality Control in SPR and BLI High-Throughput Screening Studies

May 9, 2017 - Protein-protein binding studies are only as good as the quality of the reagents used in the experiments. Great resources in terms of instrumentation, sample production and scientist time are typically invested in high-throughput screening of antibodies or fragments to obtain optimal therapeutic candidates, perform epitope binning and rank candidates by affinity and kinetics. However, often little attention is paid to verifying protein solution quality—which can lead researchers down the proverbial rabbit hole, chasing after ephemeral or anomalous results that are caused by degraded proteins. To download a white paper describing a fast, easy and non-perturbing pre-screening method using the DynaPro Plate Reader II.
April 13, 2017
Jeff Ahlgren Teaching

Wyatt Presents Polymer Characterization Seminar Hosted by the University of Minnesota

April 13, 2017 – Wyatt Technology, in partnership with the University of Minnesota, presented a polymer characterization seminar in the Twin Cities to over fifty scientists and engineers. Dr. Jeff Ahlgren was the keynote speaker and discussed ways in which size-exclusion chromatography (SEC) or gel permeation chromatography (GPC) coupled with multi-angle light scattering (MALS), refractive index (RI) and differential viscometry can be a powerful technique in determining important polymer characteristics such as: absolute molar mass, size, branching and conformation. Many of our long time and loyal customers attended and got a chance to hear about the latest developments at Wyatt Technology including the new, benchmark-setting ViscoStar III.