Wyatt Blog
We welcome blog post submissions from all Wyatt users and staff. To submit a blog, please send your article in a Word document to marketing@wyatt.com along with any photos or images in separate files.May 9, 2017
May 9, 2017 - Protein-protein binding studies are only as good as the quality of the reagents used in the experiments. Great resources in terms of instrumentation, sample production and scientist time are typically invested in high-throughput screening of antibodies or fragments to obtain optimal therapeutic candidates, perform epitope binning and rank candidates by affinity and kinetics. However, often little attention is paid to verifying protein solution quality—which can lead researchers down the proverbial rabbit hole, chasing after ephemeral or anomalous results that are caused by degraded proteins. To download a white paper describing a fast, easy and non-perturbing pre-screening method using the DynaPro Plate Reader II.
April 13, 2017
April 13, 2017 – Wyatt Technology, in partnership with the University of Minnesota, presented a polymer characterization seminar in the Twin Cities to over fifty scientists and engineers. Dr. Jeff Ahlgren was the keynote speaker and discussed ways in which size-exclusion chromatography (SEC) or gel permeation chromatography (GPC) coupled with multi-angle light scattering (MALS), refractive index (RI) and differential viscometry can be a powerful technique in determining important polymer characteristics such as: absolute molar mass, size, branching and conformation. Many of our long time and loyal customers attended and got a chance to hear about the latest developments at Wyatt Technology including the new, benchmark-setting ViscoStar III.
April 4, 2017
April 4, 2017 - Most of the boxes have been unpacked. Furniture that didn’t survive the move has been recycled. New logos have been stenciled on the glass. Our company sign has been hoisted into place on the building’s façade.
March 14, 2017
March 14, 2017 - At the recent Pittsburgh Conference (PittCon) held in Chicago, IL March 6-9, 2017, Wyatt Technology was pleasantly surprised to learn that we had won a Scientist’s Choice Award® from SelectScience. The active roster of 300,000+ SelectScience customers were invited to participate in the process by nominating, voting and reviewing companies of their choosing.
March 3, 2017
March 3, 2017 - We are pleased to announce the release of 21CFR(11)-compliant software for the groundbreaking DynaPro® Plate Reader II. The DynaPro PRII is widely used in the biopharmaceutical industry to characterize aggregation as well as thermal, conformational and colloidal stability of biotherapeutics. With the release of the 21CFR11-compliant Security Pack (SP) in DYNAMICS, labs operating under GLP or GMP regulatory requirements may now take advantage of the DynaPro PRII’s automation to measure dozens, hundreds or even thousands of samples per day. DYNAMICS SP also supports the DynaPro NanoStar cuvette-based DLS detector and the Möbius zeta potential/DLS detector.
March 3, 2017
March 3, 2017 - Ligand Binding Assays (LBAs) used for large molecule drug development often utilize proteins conjugated to various tags. To ensure that these conjugated protein reagents perform consistently over time and provide high quality data, each lot of conjugated material should be characterized functionally and biophysically. This application note, contributed by Justin Low et al. at Genentech, discusses the advantages of SEC-MALS for this application and the impact of aggregated reagents on assays used to detect anti-drug antibodies.
February 14, 2017
February 14, 2017 - Testing the stability of nanoparticles for drug delivery, phototherapy and diagnostics under physiological conditions is a critical phase of development. Bhirde et al. of the FDA and NIH have demonstrated the use of the DynaPro DLS Plate Reader for assessing the stability of model colloidal systems and their interaction with serum albumin, fully automated over many samples conditions and an extended time period.
February 2, 2017
February 2, 2017 - The ability of viruses to maximize functionality from a limited genome, and to evolve their functionalities in real time offers us fundamental insights into the capabilities and plasticity of proteins in general. In this on-demand webcast, Dr. Erica Ollmann Saphire of the Scripps Research Institute explores the versatile structural biology of viral proteins and how light scattering played a key role in her discoveries.
February 2, 2017
February 2, 2017 - Learn how high-throughput dynamic light scattering meets the challenges of aggregation and stability studies in early developability and pre-formulation studies of biotherapeutics. Newly released white paper.
January 21, 2017
January 21, 2017 - The ViscoStar III comprises breakthrough technology for online viscometry, enhancing sensitivity and resolution while improving ease-of-use and nearly eliminating sensitivity to pressure fluctuations from the HPLC pump or other sources. This white paper describes the innovations and the end benefits to users.