Waters | Wyatt Blog

We welcome blog post submissions from all Waters | Wyatt users and staff. To submit a blog, please send your article in a Word document to marketing@wyatt.com along with any photos or images in separate files.
December 15, 2017

Polymer characterization: viscosity is intrinsic

December 15, 2017 - The centrality of multi-angle light scattering to polymer characterization is widely appreciated. SEC-MALS with a DAWN® is the gold standard for determining reliable, accurate distributions of absolute molar mass and rms radius, without having to rely on column calibration, reference molecules that don’t elute like your samples, and assumptions about ideal conformation and column interactions. But once you have mastered SEC-MALS, what’s the next stage? How to obtain even deeper understanding of your macromolecules? And what are your options if SEC-MALS does not work for some of your samples?
November 14, 2017

Developing a Library of Proteins for Drug Research

November 14, 2017 - The abundance of protein drugs on the market shows there is an increasing demand for knowledge within the formulation of biologics, as Professor Pernille Harris, Principal Investigator and Coordinator of the Protein-excipient Interactions and Protein-Protein Interactions in formulation (PIPPI) project explains
October 13, 2017

Gold Seal of Quality Awarded for DAWN

October 13, 2017 - Once again our remarkable customers, along with SelectScience®, have chosen to recognize the DAWN® as an icon of instrument quality and customer delight. This month the DAWN was awarded the SelectScience Gold Seal of Quality, just the second analytical instrument in a field of thousands to receive this status.
October 4, 2017

Wyatt Customer to Win Nobel Prize in Chemistry

October 4, 2017 - Wyatt Technology congratulates its customer, Dr. Joachim Frank of Columbia University on sharing the Nobel Prize in Chemistry today with Jacques Dubochet and Richard Henderson. We are delighted to see their work developing cryo-electron microscopy recognized for its use in high-resolution structure determination of biomolecules in solution.
September 11, 2017

Virtual Method Optimization and Size Analysis for FFF

September 11, 2017 - Flow-field flow fractionation (flow-FFF) offers highly versatile separations for the analysis of complex fluids, covering a size range of macromolecules and particles from 1 nm to 10,000 nm. However, flow-FFF is often perceived as a difficult technique to learn because of the multiple parameters available for adjustment.

Our new SCOUT DPS® software simulates flow-FFF from basic physical principles, enabling the virtual optimization of flow-FFF methods and opening up the power of flow-FFF separations to non-experts. SCOUT DPS also analyzes particle size distributions (hydrodynamic radius) by elution time to increase characterization capabilities. This publication in The Column explains how it works.

August 31, 2017

UHP-SEC-MALS Analysis of NIST mAb Reference Material

August 31, 2017 - The µDAWN® multi-angle light scattering (MALS) detector was developed to meet the need for a low-volume, low-dispersion MALS instrument compatible with size-exclusion UHPLC (SE-UHPLC). Congratulations to Drs. Vincent Hsieh and Philip J. Wyatt on the publication of their article, “Measuring proteins with greater speed and resolution while reducing sample size” in Scientific Reports. The paper describes the analysis of NIST standard reference material SRM 8671, a monoclonal antibody developed to benchmark analytical instruments for the biopharmaceutical industry, with the µDAWN.
August 11, 2017

Three Wyatt Generations

August 11, 2017 - 3G isn’t just a telecommunications term anymore. It’s also an abbreviation for the three generations of Wyatts working at Wyatt Technology this summer. While there have been 2G—or two generations—of Wyatts working at Wyatt Technology for more than thirty years, this summer we welcomed Spenser Wyatt, Geof’s son, to intern under Ross Bryant, Wyatt Technology’s Vice President for Sales & Marketing, doing Market Research. Besides investigating instrument population density throughout the United States, and researching new sales tools, Spenser has audited Light Scattering University and surveyed students about their experiences at LSU.
July 1, 2017

Drug discovery: Finding, Then Losing, Then Finding Again Colloidal Aggregates of Small-molecule Drugs with DLS

July 1, 2017 - Dynamic light scattering is not just for proteins and nanoparticles. In the field of small-molecule drug discovery, high-throughput DLS with the DynaPro Plate Reader II has at least one key role - preventing the accumulation of misleading hits, or false positives, that are a result of aggregated compounds. Brian Shoichet's UCSF lab has been instrumental in elucidating the mechanism of action and prevention of these promiscuous inhibitors, utilizing the DynaPro PRII for detection and formulation. Read highlights of his publications and a link to a recent online interview.
May 31, 2017

Joining Forces for Faster Analyses

May 31, 2017 - When two technology leaders team up to advance the state of the art in polymer and biopharmaceutical characterization, customers can expect to see some real benefits coming down the pipeline. Wyatt and Waters have been collaborating for some time on joint educational efforts around UPLC®, APC and the μDAWN®, but now it is official. In the words of Cliff Wyatt, Executive Vice President of Wyatt Technology, “We’re delighted to be partnering these ‘best in class’ products to improve the accuracy and throughput of our mutual customers.” Click here to read the press release on our co-marketing agreement with Waters.