Wyatt Blog

We welcome blog post submissions from all Wyatt users and staff. To submit a blog, please send your article in a Word document to marketing@wyatt.com along with any photos or images in separate files.
December 15, 2017

Polymer characterization: viscosity is intrinsic

December 15, 2017 - The centrality of multi-angle light scattering to polymer characterization is widely appreciated. SEC-MALS with a DAWN® is the gold standard for determining reliable, accurate distributions of absolute molar mass and rms radius, without having to rely on column calibration, reference molecules that don’t elute like your samples, and assumptions about ideal conformation and column interactions. But once you have mastered SEC-MALS, what’s the next stage? How to obtain even deeper understanding of your macromolecules? And what are your options if SEC-MALS does not work for some of your samples?
December 14, 2017

Featured Customer: Charles Diesendruck

December 14, 2017 - Serial customer’ is not quite as chilling a phrase as ‘serial killer’, but still it can make us a bit nervous. We know that a serial customer’s research may be so dependent on Wyatt products that they keep coming back, again and again, to fulfill their need for yet another fresh SEC-MALS stack. A career may depend on Wyatt detectors; we don’t take that responsibility lightly! Charles Diesendruck, our Featured Customer for December 2017, is one such serial customer.
November 27, 2017

Featured Customer: John Matson

November 27, 2017 - Prof. Matson’s research focuses on the synthesis of unique polymeric and supramolecular materials with applications in signaling gas delivery, tissue engineering, and sustainability. Current areas of interest include the development of materials for delivery of hydrogen sulfide (H2S), a vital biological signaling gas, the synthesis of cone-shaped bottlebrush polymers, and the preparation of new polymers and polymer blends derived from renewable feedstocks.
November 14, 2017

Developing a Library of Proteins for Drug Research

November 14, 2017 - The abundance of protein drugs on the market shows there is an increasing demand for knowledge within the formulation of biologics, as Professor Pernille Harris, Principal Investigator and Coordinator of the Protein-excipient Interactions and Protein-Protein Interactions in formulation (PIPPI) project explains
October 13, 2017

Featured Customer: Jon Pokorski

October 13, 2017 - Nanoparticle sizing, protein buffer optimization for crystallization, biotherapeutic stability evaluation, critical aggregation or micelle concentration. These are some of the more common applications and uses of the DynaPro® Plate Reader, including the just-launched Plate Reader III. But, some of our Plate Reader customers are far more creative than the average scientist.
October 13, 2017

Gold Seal of Quality Awarded for DAWN

October 13, 2017 - Once again our remarkable customers, along with SelectScience®, have chosen to recognize the DAWN® as an icon of instrument quality and customer delight. This month the DAWN was awarded the SelectScience Gold Seal of Quality, just the second analytical instrument in a field of thousands to receive this status.
October 4, 2017

Wyatt Customer to Win Nobel Prize in Chemistry

October 4, 2017 - Wyatt Technology congratulates its customer, Dr. Joachim Frank of Columbia University on sharing the Nobel Prize in Chemistry today with Jacques Dubochet and Richard Henderson. We are delighted to see their work developing cryo-electron microscopy recognized for its use in high-resolution structure determination of biomolecules in solution.
September 19, 2017

Featured Customer: Professor Stuart Rowan

September 19, 2017 - We are pleased to announce that Prof. Stuart Rowan is our Featured Customer for September 2017. As Professor of Molecular Engineering at the University of Chicago’s Institute for Molecular Engineering, Dr. Rowan’s research focuses on the construction and properties of structurally-dynamic polymeric materials such as self-healing materials. He and his group study metallosupramolecular and stimuli-responsive polymers, cellulose nanocrystals in biomimetic and porous systems, and reversible covalent chemistry.
September 11, 2017

Virtual Method Optimization and Size Analysis for FFF

September 11, 2017 - Flow-field flow fractionation (flow-FFF) offers highly versatile separations for the analysis of complex fluids, covering a size range of macromolecules and particles from 1 nm to 10,000 nm. However, flow-FFF is often perceived as a difficult technique to learn because of the multiple parameters available for adjustment.

Our new SCOUT DPS® software simulates flow-FFF from basic physical principles, enabling the virtual optimization of flow-FFF methods and opening up the power of flow-FFF separations to non-experts. SCOUT DPS also analyzes particle size distributions (hydrodynamic radius) by elution time to increase characterization capabilities. This publication in The Column explains how it works.

August 31, 2017

UHP-SEC-MALS Analysis of NIST mAb Reference Material

August 31, 2017 - The µDAWN® multi-angle light scattering (MALS) detector was developed to meet the need for a low-volume, low-dispersion MALS instrument compatible with size-exclusion UHPLC (SE-UHPLC). Congratulations to Drs. Vincent Hsieh and Philip J. Wyatt on the publication of their article, “Measuring proteins with greater speed and resolution while reducing sample size” in Scientific Reports. The paper describes the analysis of NIST standard reference material SRM 8671, a monoclonal antibody developed to benchmark analytical instruments for the biopharmaceutical industry, with the µDAWN.