For this application note, a DAWN multi-angle laser light scattering (MALLS) detector was connected to an HPLC system with a size exclusion chromatography (SEC) column to determine the molar mass and size of a super-coiled circular duplex DNA.

For this application note, SEC-MALS was used to study the aggregation behavior of gelatin solutions as a function temperature without using denaturing agents, such as urea or SDS.

A pulp yield increase of 1-2% is possible with the addition of polysulphide (PS) in the kraft process. In this application note, we determine the PS effect on the complete polysaccharides degree of polymerization (DP) distribution.

Heparin has been used as an anticoagulant for over sixty years and one of the fundamental parameters for characterizing unfractionated heparin (UFH) is its molecular weight (MW) and MW distribution. Learn more by reading this application note.

Heparin has been used as an anticoagulant for over sixty years and one of the fundamental parameters for characterizing unfractionated heparin (UFH) is its molecular weight (MW) and MW distribution. Learn more by reading our application note.

Due to its superior separation capability, especially on molecules exceeding 50kDa, Flow Field-Flow Fractionation (Flow-FFF) is an excellent separation alternative. By coupling this technology to a Multi Angle Light Scattering (MALS) detector, such as a DAWN or miniDAWN, absolute values can be determined without making any assumptions.

The objective of the present study was to determine the effect of a ’mini-chaperone’ on the stability of mutant αA-crystallin (αAG98R) protein. αA-mini-chaperone is αA-crystallinderived peptide which stabilizes the denaturing substrate proteins and prevents them from aggregation and precipitation. Learn more by viewing our scientific poster.

Structures of folding intermediates of RNA are often poorly defined and stable intermediates can often be isolated. Pronounced differences in Rh are observed for the different folding states of Wild Type and Double Mutation RNA. Learn more by viewing our scientific poster.

Tau is specifically expressed in neural cells and crucial for the proper development and maintenance of the nervous system. Tau can form insoluble intracellular aggregates known as neurofibrillary tangles (NFTs), which are a pathological hallmark of many neurodegenerative diseases, including Alzheimers and FTDP-17. Learn more by viewing our scientific poster.

In this scientific poster, we examine the potential role of a model excipient (PEG) in stabilizing a model non-specific, self-attractive protein (lysozyme) at concentrations typical of formulations. Learn more.

Dendrimers, commonly used as controlled drug delivery vehicles, have a high degree of molecular uniformity, narrow molar weight distribution, and specific size and shape (theoretically). Learn how to characterize dendrimers by viewing our scientific poster.

A method for protein-polysaccharide conjugate size distribution analysis was developed using asymmetrical-flow field-flow fractionation (aFFF) coupled with multi-angle light scattering (MALS), ultra violet (UV) absorbance, and differential refractometry (dRI) detection. Learn more by viewing our scientific poster.