December 16, 2024

AN1901: Identification of GLP-1 analog oligomeric states using SEC-MALS

This application note demonstrates the use of size-exclusion chromatography coupled with multi-angle light scattering (SEC-MALS) under both native and denaturing conditions to identify, quantify, and characterize the monomer, oligomeric state and aggregates present in the commercial GLP-1a products and biosimilars.