July 7, 2020

WP9007: Characterizing Vaccines with Light-Scattering

This paper explains how various types of light scattering can be used to characterize vaccines. By measuring several attributes including size, shape, molar mass, and other parameters derived from these fundamental characteristics, light scattering aids in vaccine discovery, development, and manufacturing.

April 20, 2020

WP5003: DynaPro Plate Reader III Automated dynamic and static light scattering in microwell plates for fast, productive development of biologics

Where high-throughput analysis and screening of biologics is concerned, Wyatt’s DynaPro Plate Reader line of in-plate dynamic light scattering instruments has become the de facto standard, relied upon by drug product development scientists across the globe for assessing developability, pre-formulation, aggregation and stability. Learn more by reading our application note.

March 23, 2020

PL9006: Key publications on the characterization of vaccines with multi-angle and dynamic light scattering

This document lists key publications using multi-angle and dynamic light scattering for the characterization of vaccine agents such as viruses, virus-like particles, mRNA or DNA vectors, polysaccharides, and protein-polysaccharide conjugates.

February 12, 2020

Next Steps in AAV Characterization via Light Scattering Measuring AAV Critical Quality Attributes [poster]

AAV has mild immune response, able to deliver its payload to a wide range of host cells, and is becoming a prominent delivery vehicle in gene therapy. SEC-MALS method is presented for measuring total capsid particle concentration, relative capsid content, and percentage of monomer or aggregates.

January 22, 2020

AN8005: RT-MALS end-point determination of a polysaccharide depolymerization process

Current methods to monitor molar mass during polysaccharide production employ off-line SEC-MALS analysis, during which a single run can take up to 30 minutes. Real-time multi-angle light scattering (RT-MALS) saves time and ensures that the process ends as soon as the endpoint criterion is achieved. Learn more in our application note.