FFF-MALS separates and characterizes bionanoparticles such as viruses and liposomes to determine detailed distributions of size, including differential and cumulative weight-averaged fractions. Learn more by reading our application note.

With sizes ranging from 10,000 to 1,000,000,000 g/mol, only AF4 is suitable for complete separation of starch amylose and amylopectin. In combination with MALS, molar mass, size and conformation are determined as is the mass ratio of amylose to amylopectin. Learn more by reading our application note.

FFF-MALS-DLS, consisting of field-flow fractionation (FFF) combined with multi-angle light scattering (MALS) and dynamic light scattering (DLS), is a powerful tool for characterizing the size, concentration and structure of large nanoparticle ensembles.

The slow assembly of the multi-domain proteins into higher order complexes uniquely captured by CG-MALS provides direction for future studies and may help determine the mechanism of flagellar motor switch self-assembly.

In this note, we quantify the self-association of insulin at neutral pH in the absence of Zn2+ using composition-gradient multi-angle light scattering (CG-MALS). CG-MALS enables rapid, reproducible, label-free quantification of biomolecular self-association.

In this application note we present SEC-MALS-IV for absolute determination of HA properties using MALS, differential refractometry, and differential viscometry detectors in series with SEC separation.

Dynamic light scattering quickly and easily evaluates the homogeneity of a native heterodimeric protein complex under different pH conditions, and its stability.

SEC-MALS is not just for macromolecules in the tens of thousands, or hundreds of thousands, of g/mol. The application note demonstrates accurate measurements of absolute molar mass of polystyrene molecules from just hundreds of g/mol. Learn more by reading our application note.

Aqueous suspensions of nanospheres consisting of the biodegradable polyester Resomer RG 503 (0.5% w/v) were produced using the solvent deposition method. Particles with different sizes were produced by increasing the injection velocity of the acetone-polymer solution into the water. FFF-MALS measurements were compared to photon correlation spectroscopy (a.k.a. dynamic light scattering).

This note describes the analysis of multi-segmented block copolymers prepared by click-coupling of block copolymers synthesized by ATRP. The analysis is performed with triple-detection SEC-MALS combining a DAWN®, Optilab® and ViscoStar®.

Automated evaluation of the formulation-dependent stability of biotherapeutic antibodies, determining both zeta potential and the diffusion interaction parameter kD, can be accomplished with a Mobius® electrophoretic light scattering instrument.

Characterizing key parameters of different heparin lots requires multiple techniques. In this study, we compared heparin from two suppliers, including one lot modified with super-sulfated material.